The man who commissioned the construction of Palais Epstein, Gustav Ritter von Epstein, had two favourite architects: Theophil Hansen and Otto Wagner. The construction of Palais Epstein in 1868-1872 was the most important joint project of these great architects, who belonged to different generations but were linked by bonds of friendship. Epstein commissioned the firmly established Ringstrasse architect Theophil Hansen to make the design and entrusted the supervision of construction work to his young colleague, Otto Wagner.

Epstein had previously retained Otto Wagner to build the Epstein family’s summer residence at Baden - Wagner’s second independent commission. The architect also owed his third commission to Epstein’s intervention: the construction of a synagogue in Budapest. Epstein also promoted Theophil Hansen, for instance when the latter submitted a tender for the construction of the Vienna Stock Exchange building.